Learning About Breast Cancer
Central necrosis is often seen on core biopsy, and means the tumor growth rate outstripped the local blood supply, resulting in necrosis or death of the tissue. There is usually less oxygen in the center part of tumor as I understand it, which leads to less favorable anaerobic (oxygen lacking) conditions favoring growth. Pathologists don't like to see central necrosis, but it's common on biopsy. I haven't read where it dramatically worsens one's prognosis with breast cancer.